González-Rodríguez M L, Holgado M A, Sánchez-Lafuente C, Rabasco A M, Fini A
Departamento de Farmacia y Tecnología Farmacacéutica, Facultad de Farmacia, C/Profesor Garcia Gonzalez s/n, Universidad de Sevilla, 41012, Sevilla, Spain.
Int J Pharm. 2002 Jan 31;232(1-2):225-34. doi: 10.1016/s0378-5173(01)00915-2.
Alginate/chitosan particles were prepared by ionic gelation (Ca2+ and Al3+) for the sodium diclofenac release. The systems were characterized by electron microscopy and differential scanning calorimetry. The ability to release the active substance was examined as a function of some technological parameters and pH of dissolution medium. The release of sodium diclofenac is prevented at acidic pH, while is complete in a few minutes when pH is raised up to 6.4 and 7.2. The alginate/chitosan ratio and the nature of the gelifying cation allow a control of the release rate of the drug. The release mechanism was briefly discussed.
通过离子凝胶法（Ca2+和Al3+）制备了用于双氯芬酸钠释放的海藻酸盐/壳聚糖颗粒。通过电子显微镜和差示扫描量热法对该体系进行了表征。研究了活性物质的释放能力与一些工艺参数和溶解介质pH值的关系。在酸性pH值下，双氯芬酸钠的释放受到抑制，而当pH值升高到6.4和7.2时，几分钟内即可完全释放。海藻酸盐/壳聚糖的比例和凝胶化阳离子的性质可以控制药物的释放速率。对释放机制进行了简要讨论。
