Otto Sijbren, Furlan Ricardo L E, Sanders Jeremy K M
University of Cambridge, Department of Chemistry, Lensfield Road, Cambridge, UK CB2 1EW.
Drug Discov Today. 2002 Jan 15;7(2):117-25. doi: 10.1016/s1359-6446(01)02086-4.
A combinatorial library that responds to its target by increasing the concentration of strong binders at the expense of weak binders sounds ideal. Dynamic combinatorial chemistry has the potential to achieve exactly this. In this review, we will highlight the unique features that distinguish dynamic combinatorial chemistry from traditional combinatorial chemistry, and that could make a useful addition to the set of combinatorial techniques used in drug discovery.
一个通过牺牲弱结合剂来增加强结合剂浓度以响应其靶标的组合文库听起来很理想。动态组合化学有潜力恰好实现这一点。在这篇综述中，我们将突出动态组合化学与传统组合化学相区别的独特特征，这些特征可能会成为药物发现中所使用的组合技术的有益补充。
