Nielsen J O, Faber V, Poulsen H, Christoffersen P, Dietrichson O, Elling P, Iversen K, Juhl E, Petersen P
Scand J Infect Dis. 1975;7(3):173-7. doi: 10.3109/inf.1975.7.issue-3.04.
500 consecutive patients with acute viral hepatitis verified by biopsy were divided into groups of 202 patients with detectable Australia (Au) antigen and 298 patients without antigenaemia at the time of admission to hospital. Comparison was made of the initially recorded clinical, biochemical, histological and serological variables in the two groups. Judged by both histological and biochemical criteria, the acute disease was more severe in the 202 patients with Au antigen than in the 298 patients without Au antigen. Evidence is presented that this difference is possibly due more to qualitative aetiological differences between the two groups than to the duration of antigenaemia or the time of hospitalization. Thus, the demonstration of Au antigenaemia provides not only epidemiological but also relevant clinical information.
500例经活检证实为急性病毒性肝炎的连续患者被分为两组，一组为入院时可检测到澳大利亚（Au）抗原的202例患者，另一组为入院时无抗原血症的298例患者。对两组最初记录的临床、生化、组织学和血清学变量进行了比较。根据组织学和生化标准判断，202例有Au抗原的患者的急性疾病比298例无Au抗原的患者更严重。有证据表明，这种差异可能更多地归因于两组之间病因学性质的差异，而非抗原血症的持续时间或住院时间。因此，Au抗原血症的证实不仅提供了流行病学信息，还提供了相关的临床信息。
