Shalit M, Wollner S, Levo Y
Clin Exp Immunol. 1982 Mar;47(3):613-6.
Serum cryoglobulins were detected in 18 of 19 patients with type-A, and six of eight with type-B hepatitis. The predominant immunoglobulin in the cryoprecipitates was polyclonal IgM. Patients with type-A hepatitis had a significantly higher mean serum level of cryoglobulins when compared to those with type-B (106.9 vs. 20.5 micrograms/ml). IgM anti-hepatitis-A virus activity was detected in all cryoprecipitates obtained from hepatitis-A patients. Cryoglobulinemia in these patients was transient, associated with disease activity and accompanied by a marked increase in serum level of IgM. These findings are compatible with a recent hypothesis, which predicts the appearance of cryoglobulins under circumstances of enhanced stimulation of B cells in the presence of defective clearance of desialylated glycoproteins by their specific liver receptors.
19例甲型肝炎患者中有18例检测到血清冷球蛋白，8例乙型肝炎患者中有6例检测到。冷沉淀物中的主要免疫球蛋白是多克隆IgM。与乙型肝炎患者相比，甲型肝炎患者的血清冷球蛋白平均水平显著更高（106.9微克/毫升对20.5微克/毫升）。在从甲型肝炎患者获得的所有冷沉淀物中均检测到IgM抗甲型肝炎病毒活性。这些患者的冷球蛋白血症是短暂的，与疾病活动相关，并伴有血清IgM水平显著升高。这些发现与最近的一个假说是相符的，该假说预测在去唾液酸化糖蛋白通过其特异性肝受体清除存在缺陷的情况下，B细胞受到增强刺激时会出现冷球蛋白。
