弥漫性特发性骨肥厚的危险因素：一项病例对照研究。
Risk factors for diffuse idiopathic skeletal hyperostosis: a case-control study.
作者信息
Kiss C, Szilágyi M, Paksy A, Poór G
机构信息
National Institute of Rheumatology and Physiotherapy, Frankel Leó str. 38-40, Budapest, Hungary.
出版信息
Rheumatology (Oxford). 2002 Jan;41(1):27-30. doi: 10.1093/rheumatology/41.1.27.
OBJECTIVE
Diffuse idiopathic skeletal hyperostosis (DISH) is a skeletal disease characterized by ligamentous ossification of the anterolateral side of the spine. The aim of this study was to characterize risk factors associated with DISH.
METHODS
Subjects were recruited for participation in a screening survey of vertebral osteoporosis. The cases were 69 men and 62 women with DISH and the controls were 69 men and 62 women with spondylosis over the age of 50 yr. Cases and controls were matched for age and sex. Radiographs were taken according to a standardized protocol and DISH was classified using the Resnick criteria. Laboratory parameters and an interviewer-administered questionnaire were used to obtain data about exposure.
RESULTS
The mean ages of the populations with DISH and spondylosis were 65.2+/-8.8 and 65.0+/-9.1 yr respectively. Compared with controls, patients with DISH had a greater body mass index (27.8 vs 26.0 kg/m(2), P<0.05) and a higher serum level of uric acid (308 vs 288 micromol/l, P<0.05) and were more likely to have had diabetes mellitus (19.8 vs 9.1%, P<0.05).
CONCLUSION
DISH is clearly a distinct disorder with risk factors that distinguish it from other spinal degenerative diseases.
目的
弥漫性特发性骨肥厚（DISH）是一种以脊柱前外侧韧带骨化为特征的骨骼疾病。本研究的目的是确定与DISH相关的危险因素。
方法
招募受试者参与一项椎体骨质疏松筛查调查。病例组为69名男性和62名女性DISH患者，对照组为69名男性和62名女性50岁以上的脊柱病患者。病例组和对照组按年龄和性别进行匹配。根据标准化方案拍摄X光片，并使用雷斯尼克标准对DISH进行分类。通过实验室参数和访谈问卷获取暴露数据。
结果
DISH组和脊柱病组人群的平均年龄分别为65.2±8.8岁和65.0±9.1岁。与对照组相比，DISH患者的体重指数更高（27.8 vs 26.0 kg/m²，P<0.05），血清尿酸水平更高（308 vs 288 μmol/l，P<0.05），且更易患糖尿病（19.8% vs 9.1%，P<0.05）。
结论
DISH显然是一种独特的疾病，其危险因素使其有别于其他脊柱退行性疾病。
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