Eichelberger Maryna C, Sperber Ellen, Wagner Mariam, Hoshino Yasutaka, Dudas Robert, Hodgins Vicki, Marron Jennifer, Nehring Pamela, Casey Roberta, Burns Barbara, Karron Ruth, Clements-Mann Mary Lou, Kapikian Albert Z
Center for Immunization Research, Department of International Health, Johns Hopkins School of Public Health, Baltimore, Maryland, USA.
J Med Virol. 2002 Mar;66(3):407-16. doi: 10.1002/jmv.2160.
The safety, infectivity, and immunogenicity of two human-bovine reassortant rotavirus candidate vaccines were evaluated in adults, children, and infants. One of these, Wa x UK, contained a single human rotavirus gene from the Wa strain that encoded VP4 P1A specificity in a background of 10 bovine genes including the VP7 gene that encodes G6 specificity, whereas the other, Wa x (DS-1 x UK), possessed the human rotavirus VP4 gene from the Wa strain as well as the human VP7 gene from strain DS-1 that encoded G2 specificity. Each of these vaccines appeared to be well-tolerated and immunogenic in infants less than 6 months of age following a single oral dose, and therefore should be evaluated further as vaccine candidates.
