Puls R, Heusmann H, Heywang-Köbrunner S H
Klinik für Strahlenheilkunde, Charité, Campus-Virchow-Klinikum, Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin.
Radiologe. 2001 Dec;41(12):1072-9. doi: 10.1007/s001170170007.
Evaluation of wavelength-associated characteristics by transilluminating normal and pathological breast tissue.
80 in vivo and 52 in vitro measurements were carried out with a Mammaspectrograph (Siemens AG, ZFE München). 31 patients had a carcinoma and 59 patients a benign breast lesion. Measurements were performed with an increment of 10 nm, wavelengths between 550-1100 nm.
Normal and pathological breast tissue could be characterised in the area of absorption maxima of fat, water and haemoglobin. Atrophic breast tissue has a remarkable transmission minimum at 930 nm. Tumors with a high number of cells and neovascularisation showed a strong absorption over the entire "diagnostic window" and a transmission minimum at 970 nm. Below 700 nm the high concentration of haemoglobin resulted in an increase of transmission. Less wavelength-associated characteristics were seen in tumors with mastopatically-transformed surrounding tissue.
To differentiate breast tissue, transillumination has to be performed in the area of absorption maxima of fat, water and haemoglobin.
通过对正常和病理乳腺组织进行透照来评估波长相关特性。
使用乳腺光谱仪（西门子股份公司，慕尼黑ZFE）进行了80次体内和52次体外测量。31例患者患有癌症，59例患者有乳腺良性病变。测量以10nm的增量进行，波长范围在550 - 1100nm之间。
正常和病理乳腺组织可在脂肪、水和血红蛋白的吸收最大值区域进行表征。萎缩性乳腺组织在930nm处有明显的透射最小值。细胞数量多且有新生血管形成的肿瘤在整个“诊断窗口”表现出强烈吸收，在970nm处有透射最小值。在700nm以下，高浓度的血红蛋白导致透射增加。在周围组织发生乳腺化生的肿瘤中，与波长相关的特征较少。
为了区分乳腺组织，必须在脂肪、水和血红蛋白的吸收最大值区域进行透照。
