Gijón E, Cartas L, García X
Department of Physiology, School of Medicine, Universidad Nacional Autónoma de México, AP 70-250, Ciudad Universitaria, México D.F. 04510.
Proc West Pharmacol Soc. 2001;44:145-6.
Experiments were performed to evaluate lead acetate effects on the anaphylactic contraction in guinea pigs smooth muscles. Aortic rings from guinea pigs exposed to lead acetate developed an anaphylactic contraction significantly lower than the contraction induced by the antigen in controls. In the smooth muscle of the intestine, lead acetate did not modify the anaphylactic response. Lead induced immunosuppression of the anaphylactic response of aortic rings, whereas sodium acetate had no effect on the anaphylactic reaction of the guinea pig smooth muscle. The amplitude of the norepinephrine contraction was not modified by lead nor by sodium acetate.
进行实验以评估醋酸铅对豚鼠平滑肌过敏收缩的影响。暴露于醋酸铅的豚鼠主动脉环产生的过敏收缩明显低于对照组中抗原诱导的收缩。在肠道平滑肌中，醋酸铅未改变过敏反应。铅诱导主动脉环过敏反应的免疫抑制，而醋酸钠对豚鼠平滑肌的过敏反应没有影响。去甲肾上腺素收缩的幅度不受铅或醋酸钠的影响。
