Cow's urine poisoning in Nigeria. Experimental observations in mice.

The method of preparation and administration of "cow's urine" and the signs and symptoms of cow's urine poisoning have been described. Experimental investigations were carried out in mice to assess the toxicity ot this concoction. Effect of the preparation was compared with that of pure nicotine. The effect of each component used in preparing the concoction was also tested. Results of the experiments show that both "cow's urine" and nicotine cause excitement in low doses and cause convulsion and/or death in higher doses. Both also depress respiration. The role of "cow's urine" toxicity following administration to patients with convulsion and the possible aetiology of the neurological sequelae of "cow's urine" poisoning are discussed.