Umar A, Viner J L, Hawk E T
Gastrointestinal & Other Cancers Research Group, National Cancer Institute, Division of Cancer Prevention, EPN, Bethesda, Maryland 20892-7317, USA.
Ann N Y Acad Sci. 2001 Dec;952:88-108. doi: 10.1111/j.1749-6632.2001.tb02730.x.
Chemoprevention science is in flux owing to rapid advances in postgenomic technology. We have witnessed enormous advances in the areas of early detection and molecular profiling of colorectal carcinogenesis; however, unique interpretive and technologic challenges persist. Neoplastic hallmarks must be iteratively tested and validated as markers of risk, targets for intervention, and/or markers of response in order to expedite the development of preventive interventions. In this review, we highlight several of the technologies that are revolutionizing our understanding of carcinogenesis and our approach to colorectal cancer prevention.
由于后基因组技术的迅速发展，化学预防科学正在不断变化。我们已经目睹了结直肠癌发生早期检测和分子谱分析领域的巨大进展；然而，独特的解释和技术挑战依然存在。肿瘤特征必须经过反复测试和验证，作为风险标志物、干预靶点和/或反应标志物，以便加快预防性干预措施的开发。在这篇综述中，我们重点介绍了几种正在彻底改变我们对癌症发生的理解以及我们预防结直肠癌方法的技术。
