Peng Zheng-Hong, Sharma Vivek, Singleton Scott F, Gershon Paul D
Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston, Texas 77030, USA.
Org Lett. 2002 Jan 24;4(2):161-4. doi: 10.1021/ol0167715.
[structure: see text] We describe the synthesis of a chain-terminating mRNA cap dinucleotide and its use in the in vitro transcription of homogeneously capped RNA. Computer modeling strongly indicates that RNA capped with the new compound will be a substrate for cap-dependent translation.
[结构：见原文] 我们描述了一种链终止型mRNA帽状二核苷酸的合成及其在均一帽化RNA体外转录中的应用。计算机模拟有力地表明，用这种新化合物帽化的RNA将是帽依赖性翻译的底物。
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