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结核分枝杆菌和鸟分枝杆菌复合群在巨噬细胞内的传代改变了这些微生物的药物敏感性，这是通过使用巨噬细胞和II型肺泡上皮细胞进行细胞内药敏试验确定的。

Intramacrophage passage of Mycobacterium tuberculosis and M. avium complex alters the drug susceptibilities of the organisms as determined by intracellular susceptibility testing using macrophages and type II alveolar epithelial cells.

作者信息

Tomioka Haruaki, Sato Katsumasa, Sano Chiaki, Sano Keisuke, Shimizu Toshiaki

机构信息

Department of Microbiology and Immunology, Shimane Medical University, Izumo, Shimane 693-8501, Japan.

出版信息

Antimicrob Agents Chemother. 2002 Feb;46(2):519-21. doi: 10.1128/AAC.46.2.519-521.2002.

DOI:10.1128/AAC.46.2.519-521.2002
PMID:11796367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC127060/
Abstract

Mycobacterium tuberculosis and M. avium complex strains given intramacrophage passage (I-type) were compared with those cultured in a liquid medium (E-type) for their drug susceptibilities when they were replicating in Mono-Mac-6 macrophages or A-549 cells. Their intracellular susceptibilities to rifalazil, clarithromycin, and levofloxacin were decreased more in I-type organisms than in E-type organisms, except that their rifalazil susceptibility inside A-549 cells was markedly increased in I-type organisms.

摘要

将经巨噬细胞内传代培养的结核分枝杆菌和鸟分枝杆菌复合群菌株（I型）与在液体培养基中培养的菌株（E型）进行比较，观察它们在单核巨噬细胞-6或A-549细胞中复制时的药敏情况。I型菌株对利福拉齐、克拉霉素和左氧氟沙星的细胞内药敏性比E型菌株下降得更多，不过I型菌株在A-549细胞内对利福拉齐的药敏性显著增加。

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1
Intramacrophage passage of Mycobacterium tuberculosis and M. avium complex alters the drug susceptibilities of the organisms as determined by intracellular susceptibility testing using macrophages and type II alveolar epithelial cells.结核分枝杆菌和鸟分枝杆菌复合群在巨噬细胞内的传代改变了这些微生物的药物敏感性，这是通过使用巨噬细胞和II型肺泡上皮细胞进行细胞内药敏试验确定的。
Antimicrob Agents Chemother. 2002 Feb;46(2):519-21. doi: 10.1128/AAC.46.2.519-521.2002.
2
[MICs and MBCs of levofloxacin, clarithromycin, and KRM-1648 for Mycobacterium tuberculosis and M. avium complex residing in MONO-MAC-6 human macrophage-like cell and A-549 human type II alveolar epithelial cell lines].左氧氟沙星、克拉霉素和KRM-1648对驻留在MONO-MAC-6人巨噬细胞样细胞和A-549人II型肺泡上皮细胞系中的结核分枝杆菌和鸟分枝杆菌复合体的最低抑菌浓度和最低杀菌浓度
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Safety and bactericidal activity of rifalazil in patients with pulmonary tuberculosis.利福拉齐对肺结核患者的安全性及杀菌活性
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Antimicrobial activities of levofloxacin, clarithromycin, and KRM-1648 against Mycobacterium tuberculosis and Mycobacterium avium complex replicating within Mono Mac 6 human macrophage and A-549 type II alveolar cell lines.左氧氟沙星、克拉霉素和KRM-1648对在人单核巨噬细胞系Mono Mac 6和II型肺泡上皮细胞系A-549内复制的结核分枝杆菌和鸟分枝杆菌复合群的抗菌活性。
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Antimicrobial activities of benzoxazinorifamycin (KRM-1648) and clarithromycin against Mycobacterium avium-intracellulare complex within murine peritoneal macrophages, human macrophage-like cells and human alveolar epithelial cells.苯并恶嗪诺利福霉素（KRM-1648）和克拉霉素对鼠腹膜巨噬细胞、人巨噬细胞样细胞及人肺泡上皮细胞内鸟分枝杆菌复合群的抗菌活性。
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Mycobacterium tuberculosis invades and replicates within type II alveolar cells.结核分枝杆菌在II型肺泡细胞内侵袭并复制。
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