Tomioka Haruaki, Sano Chiaki, Sato Katsumasa, Shimizu Toshiaki
Department of Microbiology and Immunology, Shimane Medical University, Izumo, 693-8501, Shimane, Japan.
Int J Antimicrob Agents. 2002 Feb;19(2):139-45. doi: 10.1016/s0924-8579(01)00473-3.
We studied the activities of clarithromycin and fluoroquinolones (gatifloxacin, sitafloxacin, levofloxacin) in combination with other antimycobacterial drugs against extracellular and intramacrophage Mycobacterium avium complex (MAC). Clarithromycin potentiated the activities of rifampicin and rifalazil against both extracellular and intramacrophage MAC. In contrast, all the test quinolones exhibited antagonistic effects against extracellular MAC when combined with either clarithromycin or rifamycins. Such an antagonism was not observed for the activity of these combinations against intramacrophage MAC. Combined effects were observed with combinations of these fluoroquinolones with either ethambutol or streptomycin. Similar profiles were seen for the activities of two-drug combinations of clarithromycin or fluoroquinolones with other drugs against intramacrophage MAC isolated from pulmonary and disseminated MAC infections.
我们研究了克拉霉素与氟喹诺酮类药物（加替沙星、司帕沙星、左氧氟沙星）联合其他抗分枝杆菌药物对细胞外和巨噬细胞内鸟分枝杆菌复合体（MAC）的活性。克拉霉素增强了利福平和利福拉齐对细胞外和巨噬细胞内MAC的活性。相比之下，所有受试喹诺酮类药物与克拉霉素或利福霉素联合使用时，对细胞外MAC均表现出拮抗作用。而这些联合用药对巨噬细胞内MAC的活性未观察到这种拮抗作用。这些氟喹诺酮类药物与乙胺丁醇或链霉素联合使用时观察到了联合效应。克拉霉素或氟喹诺酮类药物与其他药物的两药联合对从肺部和播散性MAC感染中分离出的巨噬细胞内MAC的活性也观察到了类似的情况。
