化脓性链球菌的新型层粘连蛋白结合蛋白Lbp参与对上皮细胞的黏附。
Novel laminin-binding protein of Streptococcus pyogenes, Lbp, is involved in adhesion to epithelial cells.
作者信息
Terao Yutaka, Kawabata Shigetada, Kunitomo Eiji, Nakagawa Ichiro, Hamada Shigeyuki
机构信息
Department of Oral Microbiology, Osaka University Faculty of Dentistry, Suita-Osaka 565-0871, Japan.
出版信息
Infect Immun. 2002 Feb;70(2):993-7. doi: 10.1128/IAI.70.2.993-997.2002.
Abstract
The lbp gene, which encodes a laminin-binding protein (Lbp) of Streptococcus pyogenes, was found in all S. pyogenes M types. An Lbp-deficient mutant showed a significantly lower efficiency of adhesion to HEp-2 cells than did the wild-type strain. These results indicate that Lbp is one of the important S. pyogenes adhesins.
摘要
编码酿脓链球菌层粘连蛋白结合蛋白（Lbp）的lbp基因在所有酿脓链球菌M型中均被发现。与野生型菌株相比，Lbp缺陷型突变体对HEp-2细胞的黏附效率显著降低。这些结果表明Lbp是酿脓链球菌重要的黏附素之一。
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