Akbari Madeline S, Doran Kelly S, Burcham Lindsey R
Department of Immunology and Microbiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Microorganisms. 2022 Jul 25;10(8):1501. doi: 10.3390/microorganisms10081501.
spp. are an important genus of Gram-positive bacteria, many of which are opportunistic pathogens that are capable of causing invasive disease in a wide range of populations. Metals, especially transition metal ions, are an essential nutrient for all organisms. Therefore, to survive across dynamic host environments, Streptococci have evolved complex systems to withstand metal stress and maintain metal homeostasis, especially during colonization and infection. There are many different types of transport systems that are used by bacteria to import or export metals that can be highly specific or promiscuous. Focusing on the most well studied transition metals of zinc, manganese, iron, nickel, and copper, this review aims to summarize the current knowledge of metal homeostasis in pathogenic Streptococci, and their role in virulence.
链球菌属是革兰氏阳性菌的一个重要属，其中许多是机会致病菌，能够在广泛人群中引起侵袭性疾病。金属，尤其是过渡金属离子，是所有生物体必需的营养物质。因此，为了在动态的宿主环境中生存，链球菌进化出了复杂的系统来抵御金属压力并维持金属稳态，尤其是在定植和感染期间。细菌使用多种不同类型的转运系统来导入或输出金属，这些系统可能具有高度特异性或通用性。本综述聚焦于研究最为充分的锌、锰、铁、镍和铜等过渡金属，旨在总结致病性链球菌中金属稳态的现有知识及其在毒力中的作用。
