Zoja C, Morigi M, Remuzzi G
Mario Negri Institute for Pharmacological Research, Bergamo, Italy.
J Nephrol. 2001 Nov-Dec;14 Suppl 4:S58-62.
Hemolytic uremic syndrome (HUS), which is the most common cause of acute renal failure in children, is caused by Shiga toxin-producing Escherichia coli infection. This infection leads to renal and other organ microvascular thrombosis. Endothelial injury has been recognized as the trigger event in the development of microangiopathic process. Evidence suggests that leukocyte as well as platelet activation participate in endothelial damage. Intrinsic abnormalities of the complement system may also play a role in HUS.
溶血尿毒综合征（HUS）是儿童急性肾衰竭最常见的病因，由产志贺毒素大肠杆菌感染所致。这种感染会导致肾脏及其他器官的微血管血栓形成。内皮损伤被认为是微血管病变发展过程中的触发事件。有证据表明，白细胞以及血小板的激活参与了内皮损伤。补体系统的内在异常也可能在溶血尿毒综合征中起作用。
