Department of Microbiology and Immunology, University of Maryland, School of Medicine, 685 West Baltimore Street, HSF-I Suite 380, Baltimore, MD 21201, USA.
Curr Top Microbiol Immunol. 2012;357:105-36. doi: 10.1007/82_2011_172.
The kidneys are the major organs affected in diarrhea-associated hemolytic uremic syndrome (D(+)HUS). The pathophysiology of renal disease in D(+)HUS is largely the result of the interaction between bacterial virulence factors such as Shiga toxin and lipopolysaccharide and host cells in the kidney and in the blood circulation. This chapter describes in detail the current knowledge of how these bacterial toxins may lead to kidney disease and renal failure. The toxin receptors expressed by specific blood and resident renal cell types are also discussed as are the actions of the toxins on these cells.
肾脏是腹泻相关性溶血尿毒症综合征（D(+)HUS）中受影响的主要器官。D(+)HUS 中肾脏疾病的病理生理学主要是细菌毒力因子（如志贺毒素和脂多糖）与肾脏和血液循环中的宿主细胞相互作用的结果。本章详细描述了这些细菌毒素如何导致肾脏疾病和肾衰竭的现有知识。还讨论了特定血液和固有肾细胞类型表达的毒素受体以及毒素对这些细胞的作用。
