Zhuang X, Lin S, Zheng J, Wang L, Sun G, Li Y
Department of Gastroenterology, Guangzhou Military General Hospital, Guangzhou 510010, China.
Zhonghua Nei Ke Za Zhi. 2001 Jun;40(6):381-4.
To determine whether there is a relationship between Helicobacter pylori (Hp) and expression of c-met oncogene and proliferating cell nuclear antigen (PCNA) in gastric mucosal lesions, and prognostic significance of gastric carcinomas(GC).
Expression of c-met and PCNA were investigated in 145 gastric mucosal lesions by using immunohistochemistry. Hp was examined by Warthin-Starry method.
For chronic superficial gastritis (CSG), chronic atrophic gastritis and intestinal metaplasia (CAS + IM), dysplasia(DYS), early GC and advanced GC, the positive rates of c-met and PCNA were higher in IM, DYS and GC than in CSG (P < 0.05). Expressions of c-met and PCNA increased with the increasing proliferation of gastric mucosa, in rank correlation test, they had a close relationship (P < 0.01). Expressions of c-met and PCNA were correlated significantly with histologic type, serosal invasion and lymph node metastasis. In particular, the expression of c-met and PCNA were significantly higher in Borrmann type 4 GC, type 3 GC and type 1, 2 than in early GC(P < 0.05). By rank correlation test, c-met and PCNA have a close relationship (P < 0.001). Expressions of c-met of Hp positive were higher than Hp negative in intestinal GC (P < 0.05). Expressions of c-met were correlated significantly with Hp positive in CAG + IM, DYS and GC. The survival rate of patients with Hp infection was significantly poorer than that of patients with Hp non-infection.
The expression of c-met may be is associated with proliferation and malignant transformation of gastric mucosa. These results suggest that expression of c-met may be a new prognostic factor in gastric carcinoma. Hp infection and expression of c-met may be associated with in proliferation and malignant transformation of gastric mucosa. Hp infection is associated with prognosis of gastric carcinoma.
探讨幽门螺杆菌（Hp）与胃黏膜病变中c-met癌基因及增殖细胞核抗原（PCNA）表达的关系，以及对胃癌（GC）的预后意义。
采用免疫组织化学法检测145例胃黏膜病变中c-met和PCNA的表达，用Warthin-Starry法检测Hp。
在慢性浅表性胃炎（CSG）、慢性萎缩性胃炎及肠化生（CAS + IM）、异型增生（DYS）、早期胃癌和进展期胃癌中，IM、DYS和GC中c-met和PCNA的阳性率高于CSG（P < 0.05）。c-met和PCNA的表达随胃黏膜增殖程度的增加而升高，经等级相关检验，二者关系密切（P < 0.01）。c-met和PCNA的表达与组织学类型、浆膜侵犯及淋巴结转移显著相关。尤其是，Borrmann 4型胃癌、3型胃癌及1、2型胃癌中c-met和PCNA的表达明显高于早期胃癌（P < 0.05）。经等级相关检验，c-met和PCNA关系密切（P < 0.001）。肠型胃癌中Hp阳性者c-met的表达高于Hp阴性者（P < 0.05）。在CAG + IM、DYS和GC中，c-met的表达与Hp阳性显著相关。Hp感染患者的生存率明显低于Hp未感染患者。
c-met的表达可能与胃黏膜的增殖和恶性转化有关。这些结果提示，c-met的表达可能是胃癌新的预后因素。Hp感染与c-met的表达可能与胃黏膜的增殖和恶性转化有关。Hp感染与胃癌的预后有关。
