Liu Y, Hu H, Zhang J
Department of Pulmonary Medicine, Chinese PLA General Hospital, Beijing 100853.
Zhonghua Nei Ke Za Zhi. 1999 Sep;38(9):622-4.
To observe the therapeutic effect of macrolides in treating diffuse panbronchiolitis (DPB).
14- and 15-ring macrolides were used in the treatment of six confirmed cases of DPB for 3 approximately 24 months. The improvement in symptoms, X-ray findings, lung function and results of blood gas analysis was recorded.
Symptoms such as cough, sputum expectoration and exertional dyspnea alleviated significantly during the first 2 weeks. PaO(2) level, FEV(1)%, and vital capacity (VC) increased remarkably. Diffuse small nodular lesions on chest X-ray or CT decreased in size within a few months.
Macrolides have significant therapeutic effect on DPB and the patients have good tolerance to them. However, the mechanism of its action, the selection of the best macrolide, the most suitable dosage and the appropriate period of treatment still need further investigation.
观察大环内酯类药物治疗弥漫性泛细支气管炎（DPB）的疗效。
采用14元环及15元环大环内酯类药物对6例确诊的DPB患者进行治疗，疗程约3至24个月。记录症状、X线表现、肺功能及血气分析结果的改善情况。
咳嗽、咳痰及劳力性呼吸困难等症状在最初2周内明显减轻。动脉血氧分压（PaO₂）水平、第1秒用力呼气容积占预计值百分比（FEV₁%）及肺活量（VC）显著升高。胸部X线或CT上的弥漫性小结节病灶在数月内缩小。
大环内酯类药物对DPB有显著治疗效果，患者对其耐受性良好。然而，其作用机制、最佳大环内酯类药物的选择、最适宜的剂量及合适的治疗疗程仍需进一步研究。
