[HLA-DRB1等位基因与中国西部肺泡型棘球蚴病易感性的关联]
[Association of HLA-DRB1 allele and the susceptibility to alveolar echinococcosis in the west of China].
作者信息
Li F, Shi Y, Shi D
机构信息
Department of Parasistology, Tongji Medical University, Wuhan 430030, China.
出版信息
Zhonghua Yi Xue Za Zhi. 2000 Jun;80(6):414-6.
OBJECTIVE
To investigat the association of HLA-DRB1 alleles and the susceptibility to alveolar echinococcosis (AE).
METHODS
Thirty-five patients with AE in the high prevalence areas in the west of China were investigated for HLA-DRB1 gene by PCR/SSP technique. The results were compared with 104 normal healthy peoples.
RESULTS
Frequency of HLA-DRB1 * 040x was 26% in patient group, which was significantly higher than in control group (9.62%), with a relative risk (RR) of 4.45 (chi(2) = 13.67, P < 0.01), and with an etiological fraction of 0.20. Frequency of HLA-DRB1 * 0701 allele was decreased in patient group (patient 2.86%, control 13.94%; chi(2) = 6.67, P < 0.05), with preventable fraction of 0.30. While the frequencies of other DRB1 alleles were not significantly different.
CONCLUSION
Susceptibility to AE is strongly associated with the HLA-DRB1 * 040x allele. The high prevalence of human AE in this region was associated with genetic factor. HLA-DRB1 * 0701 geners resistant to Echinococcus multilocularis metacestode infection.
目的
研究HLA - DRB1等位基因与泡型包虫病（AE）易感性的关系。
方法
采用PCR/SSP技术对中国西部高流行区的35例AE患者进行HLA - DRB1基因检测，并与104名正常健康人进行比较。
结果
患者组中HLA - DRB1 * 040x的频率为26%，显著高于对照组（9.62%），相对危险度（RR）为4.45（χ² = 13.67，P < 0.01），病因分值为0.20。患者组中HLA - DRB1 * 0701等位基因频率降低（患者2.86%，对照组13.94%；χ² = 6.67，P < 0.05），可预防分值为0.30。而其他DRB1等位基因频率无显著差异。
结论
AE易感性与HLA - DRB1 * 040x等位基因密切相关。该地区人群AE的高流行与遗传因素有关。HLA - DRB1 * 0701基因对多房棘球绦虫幼虫感染具有抗性。
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