中国甘肃省35例肺泡型棘球蚴病患者的HLA-DRB1等位基因
HLA-DRB1 allele in 35 patients with alveolar echinococcosis in Gansu Province of China.
作者信息
Li Furong, Shi Youen, Shi Dazhong, Vuitton Dominique Angele, Craig Philip Simon
机构信息
Clinic Medical Research Center, Shenzhen People's Hospital, the Second Affiliated Hospital, Ji'nan University, Shenzhen 518020, China.
出版信息
Chin Med J (Engl). 2003 Oct;116(10):1557-60.
OBJECTIVE
To investigate the association between histocompatibility leukocyte antigen (HLA)-DRB1 alleles and alveolar echinococcosis (AE).
METHODS
Thirty-five patients with AE in high prevalence areas in Gansu Province of China were tested for the HLA-DRB1 gene using the polymerase chain reaction with sequence-specific primer (PCR-SSP) technique. The results were compared with those of 104 healthy individuals.
RESULTS
The frequency of the HLA-DRB1 * 040x gene was 26% in the patient group, which was significantly higher than that in the control group (9.62%) with a relative risk (RR) of 4.45 (chi(2) = 13.67, P < 0.01), and an etiological fraction (EF) of 0.20. The frequency of the HLA-DRB1 * 0701 allele was significantly lower in the patient group (2.86%) as compared to the control group (13.94%; chi(2) = 6.67, P < 0.05) with a preventable fraction (PF) of 0.30. The frequencies of other DRB1 alleles were not significantly different.
CONCLUSION
Susceptibility to AE is significantly associated with the HLA-DRB1 * 040x. HLA-DRB1 * 0701 gene might confer protection against AE in humans.
目的
研究组织相容性白细胞抗原（HLA）-DRB1等位基因与肺泡型包虫病（AE）之间的关联。
方法
采用聚合酶链反应-序列特异性引物（PCR-SSP）技术，对中国甘肃省高流行区的35例AE患者进行HLA-DRB1基因检测。将结果与104名健康个体的结果进行比较。
结果
患者组中HLA-DRB1 * 040x基因频率为26%，显著高于对照组（9.62%），相对危险度（RR）为4.45（χ² = 13.67，P < 0.01），病因分值（EF）为0.20。患者组中HLA-DRB1 * 0701等位基因频率（2.86%）显著低于对照组（13.94%；χ² = 6.67，P < 0.05），可预防分值（PF）为0.30。其他DRB1等位基因频率无显著差异。
结论
AE易感性与HLA-DRB1 * 040x显著相关。HLA-DRB1 * 0701基因可能对人类具有预防AE的作用。
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