雌激素受体基因多态性与急性心肌梗死之间的关联
[Association between estrogen receptor gene polymorphisms and acute myocardial infraction].
作者信息
Li Y, Huang X, Zhang P
机构信息
Department of Laboratory Science, Renmin Hospital, Wuhan University, Wuhan 430060, China.
出版信息
Zhonghua Yi Xue Za Zhi. 2001 Apr 10;81(7):389-92.
OBJECTIVE
To study the distribution of estrogen receptor (ER) in Chinese Hans population and the association of ER gene polymorphisms with acute myocardial infarction (AMI).
METHODS
ER genotyping was performed in 75 AMI patients and 118 controls by PCR-RFLP. The serum lipid levels of the subjects were also determined. 46 AMI patients were examined by selected coronary angiography (SCA).
RESULTS
ER allelic frequencies of X, x and P, p alleles were 0.207, 0.793; 0.169, 0.831 and 0.287, 0.713; 0.399, 0.661 in AMI and control groups respectively. There was no significant difference between the distribution of Xbal and PvaII polymorphisms in AMI group and control group (P > 0.05). The serum lipid levels and the results of SCA were also not significantly difference among genotypes in intra-group. But the distributions of PvuII genotypes were significantly different between AMI group and controls (P < 0.05).
CONCLUSION
XbaI polymorphisms are not related to AMI. But PvuII polymorphisms are associated with AMI, they might be a risk factor for AMI.
目的
研究雌激素受体（ER）在中国汉族人群中的分布情况以及ER基因多态性与急性心肌梗死（AMI）的相关性。
方法
采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术对75例AMI患者和118例对照者进行ER基因分型。同时测定受试者的血脂水平。对46例AMI患者进行选择性冠状动脉造影（SCA）检查。
结果
AMI组和对照组中X、x等位基因以及P、p等位基因的频率分别为0.207、0.793；0.169、0.831和0.287、0.713；0.399、0.661。AMI组和对照组中XbaI和PvaII多态性的分布无显著差异（P>0.05）。组内各基因型之间的血脂水平和SCA结果也无显著差异。但AMI组和对照组之间PvuII基因型的分布存在显著差异（P<0.05）。
结论
XbaI多态性与AMI无关。但PvuII多态性与AMI相关，可能是AMI的一个危险因素。
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