Gabr Y, Mahfouz M, Mohammed Y S
Acta Biol Med Ger. 1975;34(1):45-51.
The fatty acid pattern of blood serum lipids was examined by gas liquid-chromatography in 30 cases with bilharzial hepatic fibrosis, 11 cases with chronic active hepatitis accompanied by jaundice, and 28 healthy individuals as a comparison group of the same socioeconomic class of patients. In addition, the fatty acid patterns of the three major serum lipid classes, namely: cholesterol ester, phospholipids and triglycerides, were also investigated in seven cases of each group by gas liquid chromatography. The most remarkable differences were: a depression of the essential fatty acid level (linoleic and arachidonic) in both groups of patients together with a concomitant elevation of oleic acid in the bilharzial group and an elevation of oleic, palmitic, palmitoleic acids in the chronic active hepatitis group. The depression of linoleic and arachidonic acids was explained by the low fat diet intake, malnutrition, and the malabsorption factors which were frequent in all the patients studied. The elevation of monoethenoid acids was attributed to the decrease in the ability of the liver to desaturate the endogenous saturated and monounsaturated acids to polyunsaturated ones.
采用气液色谱法检测了30例血吸虫性肝纤维化患者、11例伴有黄疸的慢性活动性肝炎患者的血清脂质脂肪酸模式，并以28名来自相同社会经济阶层的健康个体作为对照组。此外，还通过气液色谱法对每组7例患者的三种主要血清脂质类别，即胆固醇酯、磷脂和甘油三酯的脂肪酸模式进行了研究。最显著的差异是：两组患者体内必需脂肪酸水平（亚油酸和花生四烯酸）均降低，同时血吸虫病组油酸升高，慢性活动性肝炎组油酸、棕榈酸、棕榈油酸升高。亚油酸和花生四烯酸降低的原因是所有研究患者中常见的低脂饮食摄入、营养不良和吸收不良因素。单烯酸升高归因于肝脏将内源性饱和和单不饱和酸去饱和为多不饱和酸的能力下降。
