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[肝硬化和慢性肝炎患者血清脂质及高级脂肪酸水平的偏差]

[Deviations in the level of serum lipids and higher fatty acids in liver cirrhosis and chronic hepatitis].

作者信息

Koĭchev K, Vurbanov G

出版信息

Vutr Boles. 1977;16(2):65-71.

PMID:878449
Abstract

Serum lipids and higher fatty acids were investigated in 141 patients with portal liver cirrhosis, 51 patients with chronic hepatitis and 40 clinically healthy subjects--controls. Lower contents of cholesterin in blood was found in the patients with liver cirrhosis as compared with the healthy as well as of total lipids, phospholipids, beta-LP, palmitic, palmitoleic, oleic linoleic and linolenic acids and considerably higher contents, of NEFA endogene heparin, LPL and blood sugar. The deviations described are more manifested in decompensated liver cirrhosis. In the patients with chronic hepatitis, as compared with the controls higher contents of cholesterin, total lipids, phospholipids, triglyceride, beta-LP, NEFA, LPL, endogene heparin, stearinic, palmitic, palmitoleic and oleic acids and blood sugar were found. In the patients with liver cirrhosis, as compared with the patients with chronic hepatitis, a lower contents of cholesterin was found as well as of total lipids, phospholipids, triglycerides, beta-LP, palmitic, palmitoleic and oleic acids and a higher contents of and blood sugar. The described deviations in the contents of serum lipid indices are with a definite regular character and can be used in the diagnosis of liver diseases.

摘要

对141例门脉性肝硬化患者、51例慢性肝炎患者及40名临床健康受试者(对照组)的血脂和高级脂肪酸进行了研究。与健康人相比,肝硬化患者血液中胆固醇含量较低,总脂质、磷脂、β-脂蛋白、棕榈酸、棕榈油酸、油酸、亚油酸和亚麻酸含量也较低,而游离脂肪酸、内源性肝素、脂蛋白脂肪酶和血糖含量则显著较高。上述偏差在失代偿性肝硬化中表现得更为明显。与对照组相比,慢性肝炎患者的胆固醇、总脂质、磷脂、甘油三酯、β-脂蛋白、游离脂肪酸、脂蛋白脂肪酶、内源性肝素、硬脂酸、棕榈酸、棕榈油酸和油酸以及血糖含量较高。与慢性肝炎患者相比,肝硬化患者的胆固醇、总脂质、磷脂、甘油三酯、β-脂蛋白、棕榈酸、棕榈油酸和油酸含量较低,血糖含量较高。血清脂质指标含量的上述偏差具有一定的规律性,可用于肝脏疾病的诊断。

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