Näse L, Hatakka K, Savilahti E, Saxelin M, Pönkä A, Poussa T, Korpela R, Meurman J H
Institute of Dentistry, University of Helsinki, Finland.
Caries Res. 2001 Nov-Dec;35(6):412-20. doi: 10.1159/000047484.
Lactobacillus rhamnosus GG, ATCC (LGG), has shown antagonism to many bacteria including mutans streptococci. This randomized, double-blind, placebo-controlled intervention study was designed to examine whether milk containing LGG has an effect on caries and the risk of caries in children when compared with normal milk. 594 children, 1-6 years old, from 18 municipal day-care centres were included. The children received the milk with meals from coded containers 5 days a week in the day-care centres for 7 months. The children's oral health was recorded at baseline and at the end, using WHO criteria. The caries risk was calculated based on clinical and microbiological data, comprising mutans streptococcus levels from dental plaque and saliva. The risk was classified as high if the child had a dmft/DMFT or initial caries score >0, and a mutans streptococcus count > or = 10(5) CFU/ml. The results showed less dental caries in the LGG group and lower mutans streptococcus counts at the end of the study. LGG was found to reduce the risk of caries significantly (OR = 0.56, p = 0.01; controlled for age and gender, OR = 0.51, p = 0.004). The effect was particularly clear in the 3- to 4-year-olds. Thus, milk containing the probiotic LGG bacteria may have beneficial effects on children's dental health.
鼠李糖乳杆菌GG（ATCC，即LGG）已显示出对包括变形链球菌在内的多种细菌具有拮抗作用。这项随机、双盲、安慰剂对照干预研究旨在检验与普通牛奶相比，含LGG的牛奶对儿童龋齿及患龋风险是否有影响。研究纳入了来自18个市立日托中心的594名1至6岁儿童。这些儿童在日托中心每周5天随餐从编码容器中饮用牛奶，持续7个月。使用世界卫生组织标准在基线和结束时记录儿童的口腔健康状况。基于临床和微生物学数据计算患龋风险，这些数据包括牙菌斑和唾液中的变形链球菌水平。如果儿童的dmft/DMFT或初始龋齿评分>0，且变形链球菌计数>或 = 10(5) CFU/ml，则风险被分类为高风险。结果显示，在研究结束时，LGG组的龋齿较少，变形链球菌计数也较低。研究发现LGG能显著降低患龋风险（比值比 = 0.56，p = 0.01；在控制年龄和性别后，比值比 = 0.51，p = 0.004）。这种效果在3至4岁的儿童中尤为明显。因此，含有益生菌LGG的牛奶可能对儿童口腔健康有益。
