Kumar R, Achari G, Mishra A, Chhabra D K
Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow - 226014, India.
Neurol India. 2001 Dec;49(4):380-3.
It is unusual for a medulloblastoma to occur in the cerebellopontine angle (CPA). Four of the total 63 cases of medulloblastoma managed in our department between 1988 to 1998, presented with a mass in the cerebellopontine angle. There were two children amongst these four patients, aged eight and nine years. The other two patients were young adults. Three patients had primary CPA medulloblastoma, while the fourth case had a recurrence in this region, following the excision of the primary vermian tumour. All the four cases were managed by gross total microsurgical excision and craniospinal irradiation. One of the two children, developed subfrontal recurrence after 1 year and 8 months of initial treatment, while the other child developed a large recurrence at primary site, within three months of post-operative irradiation. However, the adult patient developed CPA recurrence and subsequent cervical intramedullary metastasis within two and a half years of diagnosis. These three cases succumbed to their disease, between three months to thirty months of their initial management. However the fourth patient, a 20 years female with desmoplastic variant, was well at two and a half years of follow up.
髓母细胞瘤发生于小脑脑桥角（CPA）的情况并不常见。1988年至1998年期间，在我们科室接受治疗的63例髓母细胞瘤患者中，有4例表现为小脑脑桥角肿块。这4例患者中有2名儿童，年龄分别为8岁和9岁。另外两名患者为年轻成年人。3例患者为原发性小脑脑桥角髓母细胞瘤，而第4例患者在切除原发性蚓部肿瘤后，该区域出现复发。所有4例患者均接受了全切除显微手术和颅脊髓照射。两名儿童中的一名，在初始治疗1年零8个月后出现额下复发，而另一名儿童在术后放疗3个月内，在原发部位出现大面积复发。然而，成年患者在诊断后两年半内出现小脑脑桥角复发及随后的颈髓内转移。这3例患者在初始治疗后的3个月至30个月内死于疾病。然而，第4例患者是一名患有促纤维增生型变异型的20岁女性，在随访两年半时情况良好。
