汞合金填充物对健康献血者血浆中汞含量及总抗氧化活性的影响。

Influence of amalgam fillings on Hg levels and total antioxidant activity in plasma of healthy donors.

作者信息

Pizzichini M, Fonzi M, Gasparoni A, Mencarelli M, Rocchi G, Kaitsas V, Fonzi L

机构信息

Department of Biomedical Sciences, University of Siena, Italy.

出版信息

Bull Group Int Rech Sci Stomatol Odontol. 2001 May-Sep;43(2):62-7.

PMID:11799720

Abstract

In order to evaluate the influence of mercury (Hg) levels on antioxidant power in human plasma, 26 healthy people were evaluated by a dentist and their plasma analyzed for Hg content by atomic absorption and total antioxidant activity (TAA) by FRAP method. Hg plasma concentration correlated with number of amalgam restorations, suggesting that Hg released from fillings is a source of Hg in non-occupational exposed people. Fish consumption, in fact, showed no influence on Hg plasma levels, perhaps because Italian subjects examined in the present group used low quantity of fish at week or kinds of fish with light contamination. TAA negatively correlated with Hg plasma revealing a pro-oxidant role of Hg released from amalgam fillings.

摘要

为了评估汞（Hg）水平对人体血浆抗氧化能力的影响，一名牙医对26名健康人进行了评估，并通过原子吸收法分析了他们血浆中的汞含量，通过铁还原抗氧化能力（FRAP）法分析了总抗氧化活性（TAA）。血浆汞浓度与汞合金修复体数量相关，这表明从填充物中释放的汞是未从事职业暴露人群汞的一个来源。事实上，鱼类消费对血浆汞水平没有影响，这可能是因为本研究组中接受检查的意大利受试者每周食用鱼类的量较少，或者食用的是污染较轻的鱼类品种。TAA与血浆汞呈负相关，揭示了汞合金填充物释放的汞具有促氧化作用。