Lembowicz K, Skrzeczkowski L, Domański E
Acta Physiol Pol. 1975 May-Jun;26(3):275-81.
The aim of the study was to follow morphology of the prolactin producing cells in growing female rats with evoked "early androgen syndrome". The experiment was carried out on 3, 6 and 12-week-old animals. At the age of 3 weeks no changes in morphology of the prolactin cells were observed as compared to that of control animals. In 6 and 12-week-old animals the significant differences between androgenized and control animals were found. The prolactin cells differed both from those characteristic for normal females and normal males. The main characteristic features were: significantly smaller number of cells than in normal females, their stronger fluorescence and presence of large and giant prolactin cells similar to the so called "pregnancy cells". Possible factors responsible for the described above changes are discussed.
该研究的目的是追踪诱发“早期雄激素综合征”的成年雌性大鼠中催乳素分泌细胞的形态。实验在3周龄、6周龄和12周龄的动物身上进行。与对照动物相比，3周龄时催乳素细胞的形态未观察到变化。在6周龄和12周龄的动物中，发现雄激素化动物和对照动物之间存在显著差异。催乳素细胞与正常雌性和正常雄性的特征细胞均不同。主要特征如下：细胞数量明显少于正常雌性，荧光更强，存在与所谓“妊娠细胞”相似的大的和巨大的催乳素细胞。文中讨论了导致上述变化的可能因素。
