Shiino M, Rennels E G
Anat Rec. 1976 May;185(1):31-48. doi: 10.1002/ar.1091850104.
Estrogen treatment for one month in female rats caused some regression of somatotrophs, but induced an increase in the number of prolactin cells and caused these cells to hypertrophy. These stimulated prolactin cells showed extensive development of the granular endoplasmic reticulum which was often arranged in concentric whorls (Nebenkern). Most of the prolactin cells contained a small number of mature granules which were smaller in size than those of prolactin cells in control animals. These prolactin granules were round in sectioned profile and closely resembled the secretory granules of normal somatotrophs.
对雌性大鼠进行为期一个月的雌激素治疗，导致生长激素细胞出现一定程度的退化，但催乳素细胞数量增加且细胞肥大。这些受刺激的催乳素细胞显示出颗粒内质网广泛发育，其常呈同心环状排列（副核仁）。大多数催乳素细胞含有少量成熟颗粒，其尺寸小于对照动物催乳素细胞的颗粒。这些催乳素颗粒在切片轮廓中呈圆形，与正常生长激素细胞的分泌颗粒非常相似。
