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受限对流扩散对沿交换血管的团注浓度的影响。

The effect of restricted convection-diffusion on bolus concentration along an exchange vessel.

作者信息

Aberg B

出版信息

Acta Physiol Scand. 1975 Jul;94(3):289-300. doi: 10.1111/j.1748-1716.1975.tb05890.x.

DOI:10.1111/j.1748-1716.1975.tb05890.x
PMID:1180074
Abstract

If a sudden rise in solute concentration travels through a capillary system, a diffusible neutral solute passes the walls of the exchange vessels. If then the rate of passage depends on a chemical potential gradient (diffusion) and a hydrodynamical potential gradient (convection) and is sterically restricted (restricted convection-diffusion), water and low molecular weight solvents leave the filtering part of the capillary at a higher rate than the solute, causing a relative increase in its concentration. This phenomenon and the effect of an increasing pore size along the capillary is investigated in a model for an impermeable solute and two diffusible solutes, corresponding to glucose and raffinose. It is shown that in the model, the concentration fall along the capillary tends to become rectilinear.

摘要

如果溶质浓度的突然升高通过毛细血管系统传播,一种可扩散的中性溶质会穿过交换血管壁。如果此时溶质的通过速率取决于化学势梯度(扩散)和流体动力学势梯度(对流),并且在空间上受到限制(限制对流扩散),那么水和低分子量溶剂离开毛细血管的过滤部分的速率会高于溶质,导致其浓度相对增加。在一个针对不可渗透溶质和两种可扩散溶质(对应于葡萄糖和棉子糖)的模型中,研究了这种现象以及沿毛细血管孔径增加的影响。结果表明,在该模型中,沿毛细血管的浓度下降趋于呈直线状。

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