Aberg B
Acta Physiol Scand. 1975 Jul;94(3):301-8. doi: 10.1111/j.1748-1716.1975.tb05889.x.
This paper handles a model of the capillary function in the exchange of uncharged molecules between the blood and the tissue. The capillary system is subdivided into a filtering and a reabsorbing part. The exchange is assumed to occur through channels which are described in operational terms as pores. Through these pores there is a transport of solutes by concomitantly acting convection and diffusion influenced by a steric hinderance (restricted convection-diffusion). The outflux of glucose and raffinose is enhanced in the filtering pores, raffinose relatively more than glucose. In the reabsorbing pores the outward diffusion is hindered to some extent, raffinose relatively more than glucose. It is shown that the net effect of filtration and reabsorption is to increase the outflux of raffinose as compared to that of glucose. This mechanism may explain why glucose and raffinose and other small molecules appear to pass across capillary walls in proportion to their free diffusion coefficients and not in proportion to their restricted diffusion coefficients.
本文探讨了血液与组织之间不带电分子交换中的毛细血管功能模型。毛细血管系统分为滤过部分和重吸收部分。假定交换通过通道进行，这些通道在操作层面上被描述为孔隙。通过这些孔隙，溶质通过伴随作用的对流和扩散进行传输，受到空间位阻（受限对流扩散）的影响。葡萄糖和棉子糖在滤过孔隙中的流出量增加，棉子糖相对葡萄糖增加得更多。在重吸收孔隙中，向外扩散在一定程度上受到阻碍，棉子糖相对葡萄糖受到的阻碍更大。结果表明，与葡萄糖相比，滤过和重吸收的净效应是增加棉子糖的流出量。这种机制可以解释为什么葡萄糖、棉子糖和其他小分子似乎以与其自由扩散系数成比例而非与其受限扩散系数成比例的方式穿过毛细血管壁。
