Sun Xiao-Feng
Department of Oncology, Institute of Biomedicine and Surgery, Linköping University, S-581 85 Linköping, Sweden.
Clin Cancer Res. 2002 Jan;8(1):165-70.
To examine the expression of p73 in the different stages of colorectal cancer development and the association of p73 expression with patient survival.
Expression of p73 protein was evaluated by immunohistochemistry in 221 primary colorectal cancer patients, including 58 patients with matched normal mucosa and metastases in the regional lymph nodes.
Frequency and intensity of p73 expression were markedly increased from the normal samples (19%) to primary tumors (67%) and to metastases (95%). Overexpression of p73 predicted poor outcome in the whole group of patients (P = 0.014) and the subgroups with left-sided (P = 0.002) or ras-positive tumors (P = 0.019). The prognostic significance remained in the whole group (P = 0.008) and the subgroup with left-sided tumors (P = 0.019) after adjustment for the patient's sex, age, tumor stage, growth pattern, and differentiation. The p73 expression was positively correlated with ras expression (P = 0.006). The 5-year survival rates were 37, 53, 72, and 74% for the patients with p73+/ras+, p73+/ras-, p73-/ras+, and p73-/ras- tumors, respectively (P = 0.007).
Our data indicate that overexpression of p73 independently predicted poor prognosis in the patients with colorectal cancer.
研究p73在结直肠癌发展不同阶段的表达情况以及p73表达与患者生存率的关系。
采用免疫组织化学方法评估221例原发性结直肠癌患者中p73蛋白的表达，其中58例患者有匹配的正常黏膜及区域淋巴结转移灶。
p73表达的频率和强度从正常样本（19%）到原发性肿瘤（67%）再到转移灶（95%）显著增加。p73过表达预示着全组患者（P = 0.014）以及左侧肿瘤亚组（P = 0.002）或ras阳性肿瘤亚组（P = 0.019）预后不良。在对患者的性别、年龄、肿瘤分期、生长模式和分化程度进行校正后，预后意义在全组（P = 0.008）和左侧肿瘤亚组（P = 0.019）中依然存在。p73表达与ras表达呈正相关（P = 0.006）。p73+/ras+、p73+/ras-、p73-/ras+和p73-/ras-肿瘤患者的5年生存率分别为37%、53%、72%和74%（P = 0.007）。
我们的数据表明，p73过表达可独立预测结直肠癌患者的预后不良。
