[慢性阻塞性肺疾病患者的肺炎衣原体感染]

[Chlamydia pneumoniae infection in patients with chronic obstructive pulmonary disease].

作者信息

Duan Z, Liu S, Wang B

机构信息

Department of Respiratory Disease, The Second Affiliated Hospital, Hebei Medical University, Shijiazhuang 050000, China.

出版信息

Zhonghua Jie He He Hu Xi Za Zhi. 2001 Apr;24(4):208-11.

PMID:11802964

Abstract

OBJECTIVE

To investigate the association of chlamydia pneumoniae infection with chronic obstructive pulmonary disease (COPD).

METHODS

61 patients with acute exacerbations of COPD, 35 patients with stable COPD and 26 healthy subjects were selected. Chlamydia pneumoniae-specific serum IgG, IgA, IgM antibodies were measured by microimmunofluorescence method. Chlamydia pneumoniae DNA in sputum were detected by nested polymerase chain reaction.

RESULTS

The prevalence of acute chlamydia pneumoniae infection in COPD patients with acute exacerbation was significantly higher (31.1%) than that in patients with stable COPD (P < 0.05) and in healthy subjects (P < 0.01). The prevalences of chronic chlamydia pneumoniae infection in COPD patients with acute exacerbations (21.3%) and stable COPD patients (31.4%) were higher than that in healthy subjects (P < 0.05) The level of geometric mean titer of the serum IgA antibodies was the highest in COPD patients with acute exacerbations (20.5), intermediately elevated in stable COPD patients (10.8) and lowest in healthy subjects (3.6).

CONCLUSION

Acute chlamydia pneumoniae infection is a rather frequent event in acute exacerbation of COPD, and chronic chlamydia pneumoniae infection may be involved in pathogenesis of COPD.

摘要

目的

探讨肺炎衣原体感染与慢性阻塞性肺疾病（COPD）的关系。

方法

选取61例COPD急性加重期患者、35例COPD稳定期患者和26例健康对照者。采用微量免疫荧光法检测肺炎衣原体特异性血清IgG、IgA、IgM抗体。采用巢式聚合酶链反应检测痰液中肺炎衣原体DNA。

结果

COPD急性加重期患者急性肺炎衣原体感染率（31.1%）显著高于COPD稳定期患者（P<0.05）和健康对照者（P<0.01）。COPD急性加重期患者（21.3%）和稳定期患者（31.4%）的慢性肺炎衣原体感染率均高于健康对照者（P<0.05）。COPD急性加重期患者血清IgA抗体几何平均滴度最高（20.5），COPD稳定期患者中等升高（10.8），健康对照者最低（3.6）。