Shi Y, Xia X, Song Y
Department of Respirology, Nanjing General Hospital, Nanjing Military Command, Nanjing, 210002.
Zhonghua Jie He He Hu Xi Za Zhi. 1998 May;21(5):280-3.
To find out the infected rate and the clinical features of patients with acute respiratory infection caused by chlamydia pneumonia(C. pneumoniae).
A prospective study for chlamydia pneumoniae infection was conducted in 110 patients with respiratory tract infection from January to December 1995 in Nanjing. Sputum and throat swab specimens were taken and C. pneumoniae DNA were detected by polymerase chain reaction (PCR) with the HM-1-HR-1 primer pair. At the same time, serum samples were taken and immunoglobulins G and M (IgG and IgM) fractions of antibodies to C. pneumoniae were studied by microimmunofluorescence test.
Prevalence of specific IgG was 70% in patients with respiratory tract infection. Seventeen patients (16%) were serologically diagnosed as having recent C. pneumoniae infection and 12 patients (11%) had the positive PCR in sputum and/or swab specimens. The total positive rate was 23% (25/110) combining PCR with serology. Acute infection of C. pneumoniae was common in the patients with asthma (57%), pneumonia (35%), COPD (26%) and bronchitis (25%). The clinical feature between C. pneumonia infection (n = 5) and non-C. pneumonia infection (n = 85) was not significanty different.
Data suggest that Chlamydia pneumonia is an important pathogen that causes infections of the human respiratory tract and attention should be drawn to this special illness.
了解肺炎衣原体（C. pneumoniae）所致急性呼吸道感染患者的感染率及临床特征。
1995年1月至12月在南京对110例呼吸道感染患者进行了肺炎衣原体感染的前瞻性研究。采集痰液和咽拭子标本，采用HM-1-HR-1引物对通过聚合酶链反应（PCR）检测肺炎衣原体DNA。同时采集血清样本，通过微量免疫荧光试验研究肺炎衣原体抗体的免疫球蛋白G和M（IgG和IgM）组分。
呼吸道感染患者中特异性IgG的患病率为70%。17例患者（16%）血清学诊断为近期肺炎衣原体感染，12例患者（11%）痰液和/或咽拭子标本PCR检测呈阳性。PCR与血清学联合检测的总阳性率为23%（25/110）。肺炎衣原体急性感染在哮喘患者（57%）、肺炎患者（35%）、慢性阻塞性肺疾病（COPD）患者（26%）和支气管炎患者（25%）中较为常见。肺炎衣原体感染患者（n = 5）与非肺炎衣原体感染患者（n = 85）的临床特征无显著差异。
数据表明肺炎衣原体是引起人类呼吸道感染的重要病原体，应关注这种特殊疾病。
