Zhu C, Xie S, Zhang J
Tongling Nonferrous Shicheng Hospital, Anhui Province, Tongling 244000, China.
Zhonghua Jie He He Hu Xi Za Zhi. 2001 Apr;24(4):236-8.
To evaluate significance of Mycobacterium tuberculosis L forms in pathogenesis of silicotuberculosis and silicosis.
Sputum culture for Mycobacterium tuberculosis and its L forms was conducted from both silicotuberculosis and silicosis groups, and the results were compared.
Among 60 silicotuberculosis patients, 6 (10%) were sputum Mycobacterium tuberculosis culture positive, of which 5 (83%) were Mycobacterium tuberculosis L forms culture positive; 28 were sputum Mycobacterium tuberculosis L forms culture positive (positive rates in the patients with silicosis stage I, stage II, stage III were 33%, 67%, 100% respectively), with a positive rate of 47%, and a significant difference was found comparing with the frequency of detecting Mycobacterium tuberculosis (P < 0.01). All of the 30 cases with silicosis were Mycobacterium tuberculosis culture negative, however, 3 of them were sputum Mycobacterium tuberculosis L forms culture positive, accounting for 10 percent.
Sputum culture for Mycobacterium tuberculosis L forms is a convenient and rapid way to improve the detection rate of Mycobacterium tuberculosis, with a positive value in early diagnosis of silicotuberculosis by reducing misdiagnosis and underdiagnosis of this disease. Detection rate of Mycobacterium tuberculosis L forms significantly increases with deterioration of silicosis.
评估结核分枝杆菌L型在矽肺结核和矽肺发病机制中的意义。
对矽肺结核组和矽肺组患者均进行痰结核分枝杆菌及其L型培养，并比较结果。
60例矽肺结核患者中，痰结核分枝杆菌培养阳性6例（10%），其中5例（83%）痰结核分枝杆菌L型培养阳性；痰结核分枝杆菌L型培养阳性28例（矽肺Ⅰ期、Ⅱ期、Ⅲ期患者阳性率分别为33%、67%、100%），阳性率为47%，与结核分枝杆菌检出率比较差异有统计学意义（P<0.01）。30例矽肺患者痰结核分枝杆菌培养均为阴性，但其中3例痰结核分枝杆菌L型培养阳性，占10%。
痰结核分枝杆菌L型培养是提高结核分枝杆菌检出率的便捷快速方法，对减少矽肺结核的误诊和漏诊、早期诊断具有重要价值。结核分枝杆菌L型检出率随矽肺病情加重而显著升高。
