da Cunha Sérgio Souza, Rodrigues Laura C, Barreto Maurício L, Dourado Inês
Instituto de Saúde Coletiva, Federal University of Bahia, Bahia, Brazil.
Vaccine. 2002 Jan 15;20(7-8):1106-12. doi: 10.1016/s0264-410x(01)00438-8.
Data from routine surveillance during two mass immunisation campaigns (MIC) with Measles-mumps-rubella (MMR)vaccine using Leningrad-Zagreb mumps strain in two states in Brazil were analysed to estimate the risk of vaccine-related meningitis and mumps. Increase in the incidence of the two diseases was observed in both states, 3 weeks after the vaccination campaigns. The estimated number of doses applied per one case of vaccine-related meningitis ranged from 6199 (95% CI: 4854-8058) to 19,247 (95% CI: 12,648-29,513) depending on the diagnostic criteria used and state. It was 300 doses (95% CI: 286-317) for each case of mumps. The implications for vaccination policy are discussed.
对巴西两个州开展的两次使用列宁格勒-萨格勒布腮腺炎毒株的麻疹-腮腺炎-风疹（MMR）疫苗大规模免疫运动（MIC）期间的常规监测数据进行了分析，以评估疫苗相关脑膜炎和腮腺炎的风险。在这两个州，疫苗接种运动3周后，这两种疾病的发病率均有所上升。根据所使用的诊断标准和州的不同，每例疫苗相关脑膜炎的估计接种剂量数在6199（95%可信区间：4854-8058）至19247（95%可信区间：12648-29513）之间。每例腮腺炎的接种剂量为300剂（95%可信区间：286-317）。文中讨论了对疫苗接种政策的影响。
