Lombardi B, Rao N K
Am J Pathol. 1975 Oct;81(1):87-100.
The influence of several factors on the development of acute hemorrhagic pancreatitis (pancreatic necrosis) with fat necrosis in mice fed DL-ethionine with a choline-deficient diet has been investigated. The results showed that: a) the incidence of the induced disease is dependent upon the age and sex of the animals and the dietary level of ethionine; b) 100% of young female mice fed 0.5% ethionine develop acute hemorrhagic pancreatitis and die within 5 days; c) the incidence is only 10 to 20% when 0.5% ethionine is fed with either a choline-supplemented diet or with laboratory chow; and d) development of pancreatic pathology is completely prevented by the inclusion in the diet of 0.5% methionine but not by the inclusion of 0.5% adenine. Possible mechanisms whereby choline deficiency potentiates the pancreatotoxicity of ethionine in mice are discussed.
研究了几种因素对喂食含DL-乙硫氨酸的胆碱缺乏饮食的小鼠急性出血性胰腺炎（胰腺坏死）伴脂肪坏死发展的影响。结果表明：a）诱发疾病的发生率取决于动物的年龄和性别以及乙硫氨酸的饮食水平；b）喂食0.5%乙硫氨酸的年轻雌性小鼠100%发生急性出血性胰腺炎并在5天内死亡；c）当0.5%乙硫氨酸与补充胆碱的饮食或实验室饲料一起喂食时，发生率仅为10%至20%；d）饮食中添加0.5%蛋氨酸可完全预防胰腺病理发展，但添加0.5%腺嘌呤则不能。讨论了胆碱缺乏增强乙硫氨酸对小鼠胰腺毒性的可能机制。
