Yang Xinmin, Yao Linbo, Fu Xianghui, Mukherjee Rajarshi, Xia Qing, Jakubowska Monika A, Ferdek Pawel E, Huang Wei
Department of Integrated Traditional Chinese Medicine and Western Medicine, Sichuan Provincial Pancreatitis Center and West China-Liverpool Biomedical Research Center, West China Hospital, Sichuan University, Chengdu, China.
Division of Endocrinology and Metabolism, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China.
Front Physiol. 2020 Dec 23;11:614591. doi: 10.3389/fphys.2020.614591. eCollection 2020.
Acute pancreatitis is a potentially severe inflammatory disease that may be associated with a substantial morbidity and mortality. Currently there is no specific treatment for the disease, which indicates an ongoing demand for research into its pathogenesis and development of new therapeutic strategies. Due to the unpredictable course of acute pancreatitis and relatively concealed anatomical site in the retro-peritoneum, research on the human pancreas remains challenging. As a result, for over the last 100 years studies on the pathogenesis of this disease have heavily relied on animal models. This review aims to summarize different animal models of acute pancreatitis from the past to present and discuss their main characteristics and applications. It identifies key studies that have enhanced our current understanding of the pathogenesis of acute pancreatitis and highlights the instrumental role of animal models in translational research for developing novel therapies.
急性胰腺炎是一种潜在的严重炎症性疾病，可能伴有较高的发病率和死亡率。目前尚无针对该疾病的特异性治疗方法，这表明对其发病机制的研究以及新治疗策略的开发仍有持续需求。由于急性胰腺炎病程不可预测且胰腺位于腹膜后相对隐蔽的解剖位置，对人类胰腺的研究仍然具有挑战性。因此，在过去的100多年里，关于该疾病发病机制的研究严重依赖动物模型。本综述旨在总结从过去到现在不同的急性胰腺炎动物模型，并讨论它们的主要特点和应用。它确定了一些关键研究，这些研究加深了我们目前对急性胰腺炎发病机制的理解，并强调了动物模型在开发新疗法的转化研究中的重要作用。
