Rao K N, Tuma J, Lombardi B
Gastroenterology. 1976 May;70(5 PT.1):720-6.
A new experimental model has been found whereby acute hemorrhagic pancreatic necrosis with fat necrosis is induced in 100% of young female mice fed a choline-deficient diet supplemented with 0.5% DL-ethioine. The onset of the pancreatic necrosis has been shown to follow accumulation, and subsequent activation, of pancreatic zymogens with intraparenchymal formation of significant amounts of elastase, chymotrypsin, and trypsin. Evidence was obtained that the proteolytic enzymes are released also in the circulation and cause a significant drop in the content of the serum protease inhibition alpha 1-antitrypsin and alpha2-macroglobulin. Increased levels of plasma amylase were found to accompany the onset of the pancreatic necrosis.
已发现一种新的实验模型，在喂食添加0.5% DL-乙硫氨酸的胆碱缺乏饮食的100%年轻雌性小鼠中可诱发伴有脂肪坏死的急性出血性胰腺坏死。胰腺坏死的发生已被证明是在胰腺酶原积累并随后激活后，在实质内形成大量弹性蛋白酶、糜蛋白酶和胰蛋白酶所致。有证据表明，蛋白水解酶也释放到循环中，导致血清蛋白酶抑制剂α1-抗胰蛋白酶和α2-巨球蛋白的含量显著下降。发现血浆淀粉酶水平升高与胰腺坏死的发生同时出现。
