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单白化基因替换对小鼠在复合回避辨别任务中表现的影响。

Effects of single albino gene substitutions on the performance of mice in a compound avoidance-discrimination task.

作者信息

Rhoades R W, Henry K R

机构信息

University of California, Davis, CA 95616, USA.

出版信息

Physiol Behav. 1977 Jul;19(1):87-92. doi: 10.1016/0031-9384(77)90164-0.

DOI:10.1016/0031-9384(77)90164-0
PMID:11803697
Abstract

Congenic C57BL/6J mice of the +/+, +/c and c/c genotypes were tested for motoric activity, active avoidance and visual discrimination performance in a variant of the Thompson-Bryant box. The three genotypes were observed to be identical in terms of motor activity, but differed greatly with regard to both avoidance and discrimination performance. On the avoidance portion of the task the c gene appeared to act in an additive fashion, with the +/+ mice being superior to the +/c mice, which were in turn superior to the c/c animals. Visual discrimination performance, however, indicated that the + allele operated in a dominant manner; here c/c mice were found to be inferior in performance when compared to either +/+ or +/c animals while no differences were observed between the two pigmented genotypes. Therefore, under the conditions of the present experiment, the albino gene shows incomplete dominance for active avoidance behavior and recessiveness for visual discrimination performance.

摘要

对基因型为+/+、+/c和c/c的同基因C57BL/6J小鼠在汤普森-布莱恩特箱变体中进行运动活动、主动回避和视觉辨别能力测试。观察发现,这三种基因型在运动活动方面表现相同,但在回避和辨别能力方面差异很大。在任务的回避部分,c基因似乎以加性方式起作用,+/+小鼠优于+/c小鼠,而+/c小鼠又优于c/c动物。然而,视觉辨别能力测试表明,+等位基因以显性方式起作用;与+/+或+/c动物相比,c/c小鼠的表现较差,而两种有色基因型之间未观察到差异。因此,在本实验条件下,白化基因在主动回避行为中表现出不完全显性,在视觉辨别能力方面表现为隐性。

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