Söderberg Karin C, Naumburg Estelle, Anger Gert, Cnattingius Sven, Ekbom Anders, Feychting Maria
Institute of Environmental Medicine, Karolinska Institutet, Institute, Stockholm, Sweden.
Epidemiology. 2002 Jan;13(1):45-9. doi: 10.1097/00001648-200201000-00008.
In studies of magnetic field exposure and childhood leukemia, power lines and other electrical installations close to the children's homes constitute the most extensively studied source of exposure. We conducted a study to assess whether exposure to magnetic fields in infant incubators is associated with an increased leukemia risk. We identified all children with leukemia born in Sweden between 1973 and 1989 from the national Cancer Registry and selected at random one control per case, individually matched by sex and time of birth, from the study base. We retrieved information about treatment in infant incubators from medical records. We made measurements of the magnetic fields inside the incubators for each incubator model kept by the hospitals. Exposure assessment was based on measurements of the magnetic field level inside the incubator, as well as on the length of treatment. For acute lymphoblastic leukemia, the risk estimates were close to unity for all exposure definitions. For acute myeloid leukemia, we found a slightly elevated risk, but with wide confidence intervals and with no indication of dose response. Overall, our results give little evidence that exposure to magnetic fields inside infant incubators is associated with an increased risk of childhood leukemia.
在磁场暴露与儿童白血病的研究中,靠近儿童家庭的输电线及其他电气设施是研究最为广泛的暴露源。我们开展了一项研究,以评估婴儿暖箱中的磁场暴露是否与白血病风险增加有关。我们从国家癌症登记处识别出1973年至1989年在瑞典出生的所有白血病患儿,并从研究对象库中为每个病例随机选取一名对照,对照按性别和出生时间进行个体匹配。我们从医疗记录中获取了有关在婴儿暖箱中治疗的信息。我们对医院保存的每种暖箱型号内部的磁场进行了测量。暴露评估基于暖箱内磁场水平的测量以及治疗时长。对于急性淋巴细胞白血病,所有暴露定义的风险估计值均接近1。对于急性髓细胞白血病,我们发现风险略有升高,但置信区间较宽,且没有剂量反应的迹象。总体而言,我们的结果几乎没有证据表明婴儿暖箱内的磁场暴露与儿童白血病风险增加有关。