Juárez U, Antman E M
Unidad Coronaria del Instituto Nacional de Cardiología Ignacio Chávez, INCICH, Juan Badiano No. 1 Col. Secc. XVI, 14080, México, D.F.
Arch Cardiol Mex. 2001 Oct-Dec;71(4):335-44.
The use of magnesium in the current therapeutics of acute myocardial infarction is controversial. There are theoretical bases on possible benefit mechanisms of action, whereby the magnesium have unique properties of myocardial cyto-protection, mainly reperfusion injury. The fundamental aspects about metabolic vias of magnesium, and the pathophysiologic explanations for the beneficial effect of magnesium included prevention of arrhythmia, antiplatelet effect, prevention of reperfusion injury, coronary vasodilation. Deleterious effects are outlined. The results of the main trials have originated considerable discussions in the world cardiology community. The principal differences between these trials and the possible explanations in order to interpret the results are explained.
镁在当前急性心肌梗死治疗中的应用存在争议。对于其可能的有益作用机制存在理论依据，镁具有心肌细胞保护的独特特性，主要是对再灌注损伤的保护。关于镁的代谢途径的基本方面，以及镁有益作用的病理生理学解释包括预防心律失常、抗血小板作用、预防再灌注损伤、冠状动脉扩张。文中概述了有害影响。主要试验结果在世界心脏病学界引发了大量讨论。解释了这些试验之间的主要差异以及为解释结果而可能给出的解释。
