Jose M, Raghu A R, Rao N N
Department of Oral Pathology, College of Dental Surgery, Manipal 576 119, India.
Indian J Dent Res. 2001 Jul-Sep;12(3):175-9.
Recent attention has been directed towards the role of mast cells in the pathogenesis of oral lichen planus. Mast cells are responsible for trafficking of inflammatory cells into the connective tissue that in turn helps in progression and maintenance of the chronicity of oral lichen planus. In the present study we have evaluated the mast cell count and its cell types using toluidine blue stain, in oral lichen planus and compared it with oral lichenoid reactions. We have observed an increase in mast cell count in both these conditions in comparison to normal mucosa. Also, a significant difference in the types of mast cells in oral lichen planus and oral lichenoid reactions has been noted, possibly suggesting that the role of mast cell is different in these conditions.
最近，人们的注意力已转向肥大细胞在口腔扁平苔藓发病机制中的作用。肥大细胞负责将炎症细胞运输到结缔组织中，这反过来又有助于口腔扁平苔藓慢性病程的进展和维持。在本研究中，我们使用甲苯胺蓝染色评估了口腔扁平苔藓中肥大细胞的数量及其细胞类型，并将其与口腔苔藓样反应进行了比较。我们观察到，与正常黏膜相比，在这两种情况下肥大细胞数量均增加。此外，还注意到口腔扁平苔藓和口腔苔藓样反应中肥大细胞类型存在显著差异，这可能表明肥大细胞在这些情况下的作用有所不同。
