Takayama S, Murakami S, Shimabukuro Y, Kitamura M, Okada H
Department of Periodontology, Osaka University Graduate School of Dentistry, Suita, Japan.
J Dent Res. 2001 Dec;80(12):2075-9. doi: 10.1177/00220345010800121001.
We recently demonstrated that a topical application of basic fibroblast growth factor (FGF-2; bFGF) to alveolar bone defects in beagle dogs enhanced periodontal regeneration. The purpose of this study was further characterization of the biological effects of FGF-2 in non-human primates. Thirty-two inflamed furcation class II defects were surgically created in 4 male primates. The gelatinous carrier alone or the carrier containing 0.1 or 0.4% human recombinant FGF-2 was topically applied to the defects and compared with no treatment. Eight weeks after application, the periodontal regeneration in those defects was analyzed. In all FGF-2-treated sites, significant periodontal regeneration was dose-dependently observed in greater amounts than in the carrier-treated or non-treated sites. No instances of epithelial down-growth, ankylosis, or root resorption were observed in the FGF-2-treated sites. These results indicate that a topical application of FGF-2 can enhance considerable periodontal regeneration in surgically created furcation class II defects of non-human primates.
我们最近证明，向比格犬的牙槽骨缺损局部应用碱性成纤维细胞生长因子（FGF-2；bFGF）可促进牙周再生。本研究的目的是进一步表征FGF-2在非人类灵长类动物中的生物学效应。在4只雄性灵长类动物身上手术制造了32处II类炎症性根分叉缺损。将单独的凝胶状载体或含有0.1%或0.4%人重组FGF-2的载体局部应用于缺损处，并与不治疗进行比较。应用8周后，分析这些缺损处的牙周再生情况。在所有FGF-2治疗部位，均观察到明显的牙周再生，且呈剂量依赖性，再生量多于载体治疗或未治疗部位。在FGF-2治疗部位未观察到上皮向下生长、骨粘连或牙根吸收的情况。这些结果表明，局部应用FGF-2可促进非人类灵长类动物手术制造的II类根分叉缺损处的大量牙周再生。
