Atarbashi-Moghadam Fazele, Atarbashi-Moghadam Saede, Sarrafan Sadeghi Termeh, Taghipour Niloofar, Azadi Ali
Department of Periodontics, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Dental Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Adv Periodontol Implant Dent. 2025 Feb 12;17(2):90-102. doi: 10.34172/japid.2025.3487. eCollection 2025 Jun.
Fibroblast growth factor 2 (FGF2) is a signaling molecule used successfully in periodontal regeneration. This review aims to evaluate histologic evidence of the effect of FGF2 on the regeneration of periodontal ligament (PDL), cementum, and alveolar bone in animal studies.
A scoping review of the animal models was conducted to assess the histologic evidence of the effect of FGF2 on periodontal regeneration. The search was performed for English articles published until January 1, 2025. Any histologic findings regarding PDL, cementum, or bone regeneration and other outcomes such as epithelial down-growth, ankylosis, neovascularization, root resorption, and any clinical observation through histologic or radiographic analysis were considered as desired outcomes.
The MEDLINE and Scopus databases were searched, and 516 records were identified. After the screening, 22 articles met the inclusion criteria and were included in the study. The primary outcomes measured were any histologic findings regarding the regeneration of PDL, cementum, and alveolar bone. The included studies investigated the effect of FGF2 on the various periodontal defects, including 1-, 2-, and 3-wall vertical defects, circumferential defects, furcation involvement, and recession-type defects. In all types of defects, PDL, cementum, and alveolar bone formation were enhanced in most groups containing FGF2 compared to groups without FGF2. Most studies mentioned better radiographic results regarding bone formation or bone fill.
FGF2 can promote regeneration in all parts of periodontal tissue in surgically created periodontal defects in animal models, including cementum, PDL, and alveolar bone.
成纤维细胞生长因子2（FGF2）是一种在牙周再生中成功应用的信号分子。本综述旨在评估动物研究中FGF2对牙周膜（PDL）、牙骨质和牙槽骨再生影响的组织学证据。
对动物模型进行了范围综述，以评估FGF2对牙周再生影响的组织学证据。检索截至2025年1月1日发表的英文文章。任何关于PDL、牙骨质或骨再生的组织学发现以及其他结果，如上皮向下生长、骨粘连、新生血管形成、牙根吸收，以及通过组织学或影像学分析的任何临床观察，均被视为预期结果。
检索了MEDLINE和Scopus数据库，共识别出516条记录。筛选后，22篇文章符合纳入标准并纳入研究。测量的主要结果是关于PDL、牙骨质和牙槽骨再生的任何组织学发现。纳入的研究调查了FGF2对各种牙周缺损的影响，包括1壁、2壁和3壁垂直缺损、环形缺损、根分叉病变和退缩型缺损。在所有类型的缺损中，与不含FGF2的组相比，大多数含FGF2的组中PDL、牙骨质和牙槽骨形成均增强。大多数研究提到在骨形成或骨填充方面有更好的影像学结果。
在动物模型中，FGF2可促进手术造成的牙周缺损中牙周组织各部分的再生，包括牙骨质、PDL和牙槽骨。
