一种从马达加斯加雨林的绿花海桐中提取的新型三萜皂苷。

A new triterpene saponin from Pittosporum viridiflorum from the Madagascar rainforest.

作者信息

Seo Youngwan, Berger John M, Hoch Jeannine, Neddermann Kim M, Bursuker Isia, Mamber Steven W, Kingston David G I

机构信息

Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.

出版信息

J Nat Prod. 2002 Jan;65(1):65-8. doi: 10.1021/np010327t.

DOI:10.1021/np010327t

PMID:11809069

Abstract

A novel triterpenoid saponin, pittoviridoside (1), which possesses an unusual 2,3,4-trisubstituted glycosidic linkage, has been isolated from Pittosporum viridiflorum using the engineered yeast strains 1138, 1140, 1353, and Sc-7 for bioactivity-guided fractionation. The structure of this compound was determined to be 3-O-[beta-D-glucopyranosyl(1-->2)]-[alpha-D-arabinopyranosyl(1-->3)],[alpha-l-arabinofuranosyl(1-->4)-beta-D-glucuronopyranosyl-21-angeloyl-22-senecioylolean-12-en-3beta,15alpha,16alpha,21beta,22alpha,28-hexol by spectral, chemical, and GC analyses. This compound showed weak cytotoxicity against the A2780 human ovarian cancer cell line.

摘要

一种新型三萜皂苷，绿花 Pittosporum viridiflorum 苷（1），其具有不寻常的 2,3,4 - 三取代糖苷键，已使用工程酵母菌株 1138、1140、1353 和 Sc - 7 通过生物活性导向分级分离从绿花海桐中分离得到。通过光谱、化学和气相色谱分析确定该化合物的结构为 3 - O - [β - D - 吡喃葡萄糖基(1→2)] - [α - D - 吡喃阿拉伯糖基(1→3)]，[α - L - 阿拉伯呋喃糖基(1→4) - β - D - 葡萄糖醛酸吡喃糖基 - 21 - 当归酰基 - 22 - 千里光酰基齐墩果 - 12 - 烯 - 3β,15α,16α,21β,22α,28 - 己醇。该化合物对 A2780 人卵巢癌细胞系显示出较弱的细胞毒性。