Jin Hui Zi, Hwang Bang Yeon, Kim Hang Sub, Lee Jeong Hyung, Kim Young Ho, Lee Jung Joon
Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yusong, Taejon 305-600, Korea.
J Nat Prod. 2002 Jan;65(1):89-91. doi: 10.1021/np010428r.
Two new sesquiterpene esters, 1beta,8beta-diacetoxyl-6alpha,9alpha-difuroyloxydihydro-beta-agarofuran (1) and 1beta-acetoxyl-2beta,6alpha,9alpha-trifuroyloxydihydro-beta-agarofuran (2), together with four known sesquiterpene esters (3-6), celastrol (7), and celaphanol A (8) were isolated from the roots of Celastrus orbiculatus in a search for inhibitors of NF-kappaB activation and nitric oxide production. Compound 7 was the most active, while compounds 1, 2, 4, and 8 showed moderate inhibition in both NF-kappaB activation and nitric oxide production.
为寻找核因子κB（NF-κB）激活和一氧化氮产生的抑制剂，从南蛇藤根部分离出两种新的倍半萜酯，1β,8β-二乙酰氧基-6α,9α-二呋喃甲酰氧基二氢-β-agarofuran（1）和1β-乙酰氧基-2β,6α,9α-三呋喃甲酰氧基二氢-β-agarofuran（2），以及四种已知的倍半萜酯（3 - 6）、雷公藤红素（7）和南蛇藤醇A（8）。化合物7活性最强，而化合物1、2、4和8在NF-κB激活和一氧化氮产生方面均表现出中等抑制作用。
