Guo Y-Q, Li X, Lee J-J, Xu J, Li N, Meng D-L, Wang J-H
Research Department of Natural Medicine, Shenyang Pharmaceutical University, Shenyang, 110016, China.
J Asian Nat Prod Res. 2006 Dec;8(8):739-42. doi: 10.1080/10286020412331286498.
A new beta-dihydroagarofuran sesquiterpene ester, 1beta,2beta,6alpha, 13-tetraacetoxy-9alpha-cinnamoyloxy-beta-dihydroagarofuran (1), and the known compound 1beta,6alpha,13-triacetoxy-9alpha-benzoyloxy-beta-dihydroagarofuran (2), have been isolated from the fruits of Celastrus orbiculatus Thunb. Their structures have been elucidated on the basis of spectroscopic methods. Compound 1 shows moderate activity of inhibiting LPS-induced nitric oxide production in murine macrophage RAW264.7 cells, with an IC50 of 55.4 microM.
从南蛇藤果实中分离得到了一种新的β-二氢沉香呋喃倍半萜酯，1β,2β,6α,13-四乙酰氧基-9α-肉桂酰氧基-β-二氢沉香呋喃（1）以及已知化合物1β,6α,13-三乙酰氧基-9α-苯甲酰氧基-β-二氢沉香呋喃（2）。通过光谱方法阐明了它们的结构。化合物1在小鼠巨噬细胞RAW264.7细胞中表现出对脂多糖诱导的一氧化氮生成的中等抑制活性，IC50为55.4微摩尔。
