Ren Jason Q, McCarthy William R, Zhang Hongwei, Adolph Alan R, Li Lei
Department of Physiology, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536, USA.
Vision Res. 2002 Feb;42(3):293-9. doi: 10.1016/s0042-6989(01)00284-x.
Zebrafish possess three classes of chromatophores that include iridophores, melanophores, and xanthophores. Mutations that lack one or two classes of chromatophores have been isolated or genetically constructed. Using a behavioral assay based on visually mediated escape responses, we measured the visual response of fully and partially pigmented zebrafish. In zebrafish that lack iridophores (roy mutants), the behavioral visual responses were similar to those of wild-type animals except at low contrast stimulation. In the absence of melanophores (albino mutants) or both melanophores and iridophores (ruby mutants), the behavioral visual responses were normal under moderate illumination but reduced when tested under dim or bright conditions or under low contrast stimulation. Together, the data suggest that screening pigments in the retina play a role in the regulation of behavioral visual responses and are necessary for avoiding "scatter" under bright light conditions.
斑马鱼拥有三类色素细胞，包括虹彩细胞、黑素细胞和黄色素细胞。已经分离或通过基因构建获得了缺乏一类或两类色素细胞的突变体。我们使用基于视觉介导的逃避反应的行为测定法，测量了完全色素沉着和部分色素沉着的斑马鱼的视觉反应。在缺乏虹彩细胞的斑马鱼（roy突变体）中，行为视觉反应与野生型动物相似，只是在低对比度刺激下有所不同。在缺乏黑素细胞（白化突变体）或同时缺乏黑素细胞和虹彩细胞（ruby突变体）的情况下，行为视觉反应在中等光照下正常，但在昏暗或明亮条件下或低对比度刺激下测试时会降低。总之，数据表明视网膜中的筛选色素在行为视觉反应的调节中起作用，并且是在强光条件下避免“散射”所必需的。
