Infertility in women with apparently ovulatory cycles. I. Comparison of their plasma sex steroid and gonadotrophin profiles with those in the normal cycle.

Serial daily plasma profiles of luteinizing hormone (LH), follicle stimulating hormone (FSH), progesterone, 17alpha-hydroxyprogesterone and oestradiol 17beta throughout single menstrual cycles from seven patients with a history of infertility but with normal menstrual rhythm and no apparent ovarian dysfunction were compared with those from apparently normally menstruating women. This comparison showed that the infertile group produced poor corpora lutea after poor follicular growth. The poor follicular growth may be related to depressed pituitary release of FSH in response to a negative feedback effect of elevated progesterone levels.